Animal Pharm: Feeding the Microbiota: Non-Starch Polysaccharides (NSP), Resistant Starch (RS) and Mucous
For SIBO and intestinal permeability, it's actually healing to minimize fermentation if it is occurring pathogically in the small intestines... where it shouldn't be. The surface of the small intestines is not designed to support extensive networks of microbial growth which requires thick mucous. The integrity of the small intestines can easilybe compromised and fail to serve its function (digestion and absorption) when inappropriate growth manages to perpetuate whether it's'good' v 'pathogenic' bacteria, yeasts or mycobacteria or parasites/worms.
Diet absolutely shifts bacterial communities in the gut ecology -- simple sugars lowers the good, raises the bad. More fiber and RS both raise the good (in Bacteroidetes -- Prevotella, etc), lowers the bad (in Firmicutes -- virulent strains of clostridas, E. coli's, enterococci, streps). This is borne out in pig, children and human studies. Flint et al do a great review here which includes a raffinose study (fiber from legumes) that enriched and ↑ F. prausnitzii, Bifidobacterium spp.
Like many of the good gut flora, Bifidobacter tightens up the intestinal tight junctions as super tight as a nun's **ss,
which is enteroproctive and immunoprotective again gastroenteritis, intestinal permeability and necrotizing enterocolitis in trials. Guess
what? Magnesium deficiency compromises Bifidobacter and intestinal permeability (or which came first?). Bifido appears to enjoy magnesium. Inrodent studies fed a mag-deficient diet, intestinal permeability and quantitative changes to cecal bifidobacteria were associated.
Below is a human study n=10 on the microbiota shifts comparing RS2 and
RS4 intakes (55 grams/day x3wks, then 2 wk washout). Even among
resistant starches, there is selective species enrichment.
The authors state in the results: "Ten human subjects consumed crackers
for three weeks each containing either RS2, RS4, or native starch in a
double-blind, crossover design. Multiplex sequencing of 16S rRNA tags
revealed that both types of RS induced several significant compositional
alterations in the fecal microbial populations, with differential
effects on community structure.
RS4 but not RS2 induced phylum-levelchanges, significantly increasing Actinobacteria and Bacteroidetes (+++) while decreasing Firmicutes(-). At the species level, the changes evoked by RS4 were increases in Bifidobacterium adolescentis and Parabacteroides distasonis, while RS2 significantly raised the proportions of Ruminococcus bromii and Eubacterium rectale
when compared to RS4. The population shifts caused by RS4 were numerically substantial for several taxa, leading for example, to a ten-fold increase in bifidobacteria in three of thesubjects, enriching them to 18–30% of the fecal microbial community. Theresponses to RS and their magnitudes variedbetween individuals, and they were reversible and tightly associated with the consumption of RS."
Shifting Microbiota Communities: GI Fx Stool Test and Optimal Nutri Eval (ONE)
Would you like to do a GI fx stool test and see your microbiota and do a
ONE to evaluate nutrient deficiencies, dysbiotic markers and 8OHdG (DNA
damage)? Let me know and show me! (Cost $99 and $129, respectively,
plus admin fee $50). Let's conduct paleo gut experiments.
Brent Pottenger's case: Recall his Prevotella, Bacteroidetes and Firmicutes are quite stunning
and no biomarkers of dysbiosis. He has likely very little mercury (no
history of cavities). His diet: near carnivory, fermented full fat Greek
+ some veggies both raw/cook (per Pottenger's cats). The microbiota
sequencing reveals a beautiful display of healthy guts. Previously he
c/o acne and migraines which are signs of SIBO and intestinal
permeability.
My case: The Prevotella, Bacteroidetes and Firmicutes (2013)
are impressively improved and robust compared with the initial 2011
when I had CFS, fogginess, fraility (sarcopenia), rank mood, and on/off
body fat. The SIBO is gone except for residual dysbiotic biomarkers
from a parasite and Morganella.
What had I done?
--for two years
For SIBO and intestinal permeability, it's actually healing to minimize fermentation if it is occurring pathogically in the small intestines... where it shouldn't be. The surface of the small intestines is not designed to support extensive networks of microbial growth which requires thick mucous. The integrity of the small intestines can easilybe compromised and fail to serve its function (digestion and absorption) when inappropriate growth manages to perpetuate whether it's'good' v 'pathogenic' bacteria, yeasts or mycobacteria or parasites/worms.
Diet absolutely shifts bacterial communities in the gut ecology -- simple sugars lowers the good, raises the bad. More fiber and RS both raise the good (in Bacteroidetes -- Prevotella, etc), lowers the bad (in Firmicutes -- virulent strains of clostridas, E. coli's, enterococci, streps). This is borne out in pig, children and human studies. Flint et al do a great review here which includes a raffinose study (fiber from legumes) that enriched and ↑ F. prausnitzii, Bifidobacterium spp.
Like many of the good gut flora, Bifidobacter tightens up the intestinal tight junctions as super tight as a nun's **ss,
which is enteroproctive and immunoprotective again gastroenteritis, intestinal permeability and necrotizing enterocolitis in trials. Guess
what? Magnesium deficiency compromises Bifidobacter and intestinal permeability (or which came first?). Bifido appears to enjoy magnesium. Inrodent studies fed a mag-deficient diet, intestinal permeability and quantitative changes to cecal bifidobacteria were associated.
Below is a human study n=10 on the microbiota shifts comparing RS2 and
RS4 intakes (55 grams/day x3wks, then 2 wk washout). Even among
resistant starches, there is selective species enrichment.
for three weeks each containing either RS2, RS4, or native starch in a
double-blind, crossover design. Multiplex sequencing of 16S rRNA tags
revealed that both types of RS induced several significant compositional
alterations in the fecal microbial populations, with differential
effects on community structure.
RS4 but not RS2 induced phylum-levelchanges, significantly increasing Actinobacteria and Bacteroidetes (+++) while decreasing Firmicutes(-). At the species level, the changes evoked by RS4 were increases in Bifidobacterium adolescentis and Parabacteroides distasonis, while RS2 significantly raised the proportions of Ruminococcus bromii and Eubacterium rectale
when compared to RS4. The population shifts caused by RS4 were numerically substantial for several taxa, leading for example, to a ten-fold increase in bifidobacteria in three of thesubjects, enriching them to 18–30% of the fecal microbial community. Theresponses to RS and their magnitudes variedbetween individuals, and they were reversible and tightly associated with the consumption of RS."
Shifting Microbiota Communities: GI Fx Stool Test and Optimal Nutri Eval (ONE)
Would you like to do a GI fx stool test and see your microbiota and do a
ONE to evaluate nutrient deficiencies, dysbiotic markers and 8OHdG (DNA
damage)? Let me know and show me! (Cost $99 and $129, respectively,
plus admin fee $50). Let's conduct paleo gut experiments.
Brent Pottenger's case: Recall his Prevotella, Bacteroidetes and Firmicutes are quite stunning
and no biomarkers of dysbiosis. He has likely very little mercury (no
history of cavities). His diet: near carnivory, fermented full fat Greek
+ some veggies both raw/cook (per Pottenger's cats). The microbiota
sequencing reveals a beautiful display of healthy guts. Previously he
c/o acne and migraines which are signs of SIBO and intestinal
permeability.
My case: The Prevotella, Bacteroidetes and Firmicutes (2013)
are impressively improved and robust compared with the initial 2011
when I had CFS, fogginess, fraility (sarcopenia), rank mood, and on/off
body fat. The SIBO is gone except for residual dysbiotic biomarkers
from a parasite and Morganella.
What had I done?
--for two years
- gluten free, casein free, exercise/yoga (some barefoot on soil/lawn)
- removed mercury, gold, titanium parts and oral chelation on/off
- sleep, adrenal/gut support, antioxidants incl pycnogenol, omega-3, minerals
- Prescript Assist, FloraMend
- whole food diet (rainbow tubers, veggies, organic meat, lard/ghee)
- fermented pao cai, Beijing radishes, carrots
- Seed: Raw unpasteruized sauerkraut at nearly every meal and drank the brine, SBO probiotics
- Weed: charcoal and bentonite clay; removed gut irritants (alcohol -- studies here and here)
- Feed: Kraut and fiber rich foods (basmati rice, vegetables, potatoes, etc)
